Several recent studies have made the case that acne and depression are highly correlated. This makes it hard to gauge whether a drug like Lexapro worsens acne, because the average Lexapro user is highly likely to experience acne whether or not he/she takes the drug.
Up to 15% of Lexapro users experience insomnia. This alone is likely to lead to acne, as there is a strong correlation between low quality sleep and acne breakouts. Other possible side effects that could affect your skin are weight gain and indigestion, both indicating a likelihood that your body may not be digesting key nutrients, or that you are eating increasing amounts of high glycemic index junk food, another item studies have shown likely to aggravate / cause acne.
Do you have experience with Lexapro? If so, please tell us about how it affected your skin, if at all, below.