Wellbutrin is a prescription drug that is used to treat anxiety and depression, two conditions which are highly correlated with acne (check out the studies page of our site). It is not known whether depression causes acne, acne causes depression, or a 3rd factor causes both. Regardless, it is unlikely but not impossible for Wellbutrin to cause acne. However, if you do experience acne while taking Wellbutrin, you should consider that it is likely a by-product of depression / anxiety, and not directly related to Wellbutrin.
Does Wellbutrin correlate with acne in your experience? Please tell us your thoughts.


Are you kidding? Do you have acne? Serious cystic, long-term and/or hereditary? How can you say depression CAUSES acne and not visa versa? Sure because 90% of Americans do not follow these dietary guidelines and many also have depression. But for the 10% who do, this is really hard to listen to.
I have been on Wellbutrin for a couple months and I’ve never had acne this bad. My entire back is covered with pimples. I also have been getting deep red pimples on my face, mostly my chin and forehead. I have also been through a breakup so that may be the cause, but I’ve been feeling better lately, and the acne doesn’t seem to be clearing up.
Wellbutrin can cause anxiety in some, so maybe that can increase acne.
I’ve been on zoloft/wellbutrin for the past few months, and the skin on my face (but nowhere else) has erupted into huge cysts that I’d never had problems with before. I wouldn’t say that acne and depression are related in my case. When I was depressed, my skin was clearer than it had ever been. Now that I’m stress-free and stable, it’s worse than ever (though I’ve learned to not let it destroy my self-esteem).
For the record, I also eat healthy (I log everything onto caloriecount.com to check my nutrition levels, since I’m a vegetarian and on a budget), try to eat organic and pesticide-free produce as often as possible, exercise daily, drink the recommended 8 cups of water a day, sleep regularly at night, wash my face twice daily with gentle cetaphil facewash, wear spf 100 sunscreen and lotion every time I go out, practice yoga and meditate, wash/change my sheets and pillowcases every week, vacuum and dust every week, take a daily mutivitamin supplement along with fish oil and cranberry powder, and keep my hair out of my face as much as possible.
The only thing that’s change within the past few months (during which my skin broke out) has been the addition of Zoloft (50 mg) and Wellbutrin (150 mg) into my daily life.
All evidence in my mind points to one of the two being the cause of this otherwise random outbreak, but of course I’m always open to other suggestions (especially since the medication has worked amazingly well for my depression).
most of my face has broken out within about a week of starting wellbutrin. i’ve been taking paroxatine for depression for years, and had well-managed acne until now. sigh.
My husband started Wellbutrin recently, and he just upped the dose to 300 mg a day a couple of days ago. Today we saw that he is breaking out like crazy all over, especially on his legs. Definitely think it’s the Wellbutrin as nothing else has really changed.
Will watch out for hair loss too..
I have been taking Wellbutrin for only 2 weeks and have started getting cystic acne, mostly on my chin and jawline. I eat properly, get enough rest, etc and wellbutrin is the only change I’ve made. As of today I quit taking it. Sometimes the “cure” is worse than the problem.
PS – I would stress to any who read my comment, don’t stop any medication without checking with your doctor.
Wellbutrin caused me serious complications with scalp acne and random cysts. I thought it was related to bacteria or something else, but I stopped taking it for a few days because of the way my paychecks/prescription coincided and the acne/cysts cleared up. I’d been taking it for almost a year and been battling with the acne for about 3 months. One time I’m glad I ran out of my meds!
I have been taking wellbutrin for about two and a half months now, and my skin has never been clearer. I have dealt with acne for as long as I can remember (I’m 23 now). For those of us who have dealt with it, you know it can be a real confidence buster. Sure I’ve gone through phases of harsh acne and light acne… but seriously, it’s never been clear for this long, and the only thing I can think of as the reason is the wellbutrin. I suppose depression and/or anxiety were my major causes for acne. I’m sure it is different for everyone though. I have never been happier with my skin.