Wellbutrin & Acne

Wellbutrin is a prescription drug that is used to treat anxiety and depression, two conditions which are highly correlated with acne (check out the studies page of our site). It is not known whether depression causes acne, acne causes depression, or a 3rd factor causes both. Regardless, it is unlikely but not impossible for Wellbutrin to cause acne. However, if you do experience acne while taking Wellbutrin, you should consider that it is likely a by-product of depression / anxiety, and not directly related to Wellbutrin.

Does Wellbutrin correlate with acne in your experience? Please tell us your thoughts.

9 Responses to “Wellbutrin & Acne”

  1. Samantha 29. Mar, 2011 at 1:48 pm #

    Are you kidding? Do you have acne? Serious cystic, long-term and/or hereditary? How can you say depression CAUSES acne and not visa versa? Sure because 90% of Americans do not follow these dietary guidelines and many also have depression. But for the 10% who do, this is really hard to listen to.

  2. Lila 25. Apr, 2011 at 4:26 pm #

    I have been on Wellbutrin for a couple months and I’ve never had acne this bad. My entire back is covered with pimples. I also have been getting deep red pimples on my face, mostly my chin and forehead. I have also been through a breakup so that may be the cause, but I’ve been feeling better lately, and the acne doesn’t seem to be clearing up. :( Wellbutrin can cause anxiety in some, so maybe that can increase acne.

  3. ds24 20. May, 2011 at 1:03 pm #

    I’ve been on zoloft/wellbutrin for the past few months, and the skin on my face (but nowhere else) has erupted into huge cysts that I’d never had problems with before. I wouldn’t say that acne and depression are related in my case. When I was depressed, my skin was clearer than it had ever been. Now that I’m stress-free and stable, it’s worse than ever (though I’ve learned to not let it destroy my self-esteem).

    For the record, I also eat healthy (I log everything onto caloriecount.com to check my nutrition levels, since I’m a vegetarian and on a budget), try to eat organic and pesticide-free produce as often as possible, exercise daily, drink the recommended 8 cups of water a day, sleep regularly at night, wash my face twice daily with gentle cetaphil facewash, wear spf 100 sunscreen and lotion every time I go out, practice yoga and meditate, wash/change my sheets and pillowcases every week, vacuum and dust every week, take a daily mutivitamin supplement along with fish oil and cranberry powder, and keep my hair out of my face as much as possible.

    The only thing that’s change within the past few months (during which my skin broke out) has been the addition of Zoloft (50 mg) and Wellbutrin (150 mg) into my daily life.

    All evidence in my mind points to one of the two being the cause of this otherwise random outbreak, but of course I’m always open to other suggestions (especially since the medication has worked amazingly well for my depression).

  4. lauren 08. Jul, 2011 at 12:00 pm #

    most of my face has broken out within about a week of starting wellbutrin. i’ve been taking paroxatine for depression for years, and had well-managed acne until now. sigh.

  5. Eve 10. Aug, 2011 at 4:13 pm #

    My husband started Wellbutrin recently, and he just upped the dose to 300 mg a day a couple of days ago. Today we saw that he is breaking out like crazy all over, especially on his legs. Definitely think it’s the Wellbutrin as nothing else has really changed.

    Will watch out for hair loss too..

  6. dianalia 15. Jan, 2012 at 7:20 am #

    I have been taking Wellbutrin for only 2 weeks and have started getting cystic acne, mostly on my chin and jawline. I eat properly, get enough rest, etc and wellbutrin is the only change I’ve made. As of today I quit taking it. Sometimes the “cure” is worse than the problem.

  7. dianalia 15. Jan, 2012 at 7:23 am #

    PS – I would stress to any who read my comment, don’t stop any medication without checking with your doctor.

  8. larrya 06. Feb, 2012 at 7:29 am #

    Wellbutrin caused me serious complications with scalp acne and random cysts. I thought it was related to bacteria or something else, but I stopped taking it for a few days because of the way my paychecks/prescription coincided and the acne/cysts cleared up. I’d been taking it for almost a year and been battling with the acne for about 3 months. One time I’m glad I ran out of my meds!

  9. Claire 10. Feb, 2012 at 11:03 pm #

    I have been taking wellbutrin for about two and a half months now, and my skin has never been clearer. I have dealt with acne for as long as I can remember (I’m 23 now). For those of us who have dealt with it, you know it can be a real confidence buster. Sure I’ve gone through phases of harsh acne and light acne… but seriously, it’s never been clear for this long, and the only thing I can think of as the reason is the wellbutrin. I suppose depression and/or anxiety were my major causes for acne. I’m sure it is different for everyone though. I have never been happier with my skin.

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How to clear your skin:



Vitamins / Supplements

With a meal, 3-4 times per day: 3 mgs of boron, Vitamin B Complex 50, 25-50 mgs of Zinc. Once per day, with a meal: Multi vitamin, Fish Oil (Not Cod Liver Oil), 2000 IUs of Vitamin D. This alone may end acne.

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Get outside during the day!

You need daylight to suppress melatonin so you can really crank it out at night. Stay in the shade, but you must see sky. 12+ hours is optimal, an hour in the am and at noon may work. No sunburns, sunglasses or hats!

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Fix your sleep cycle

Go to sleep at the same time every night. Ten o'clock is optimal. Sleep in complete darkness, and wake up without an alarm. 8.5+ hours is best. Try to keep your evening activities calm and in relative darkness. It is nearly impossible to improve acne without sleeping properly.

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Get your exercise

Workout for 30-60 minutes, 4-5 hours before bedtime, every day. Eat meat beforehand (within an hour). You are moving Tryptophan into the brain. Additional exercise is great, but never close to bedtime. Outdoor exercise is best. Make sure you work up a good sweat.

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Eat the right things

Eliminate gluten, dairy and processed foods altogether. Cut back on soy and sugars including fruit. Use unlimited extra virgin olive oil, but no soy / vegetable / other oils. Eat tomatoes cooked in olive oil (or tomato juice), carrots, and broccoli every day. Eat sunflower seeds or pumpkin seeds before bedtime.

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Other Stuff

Wash only twice/day. Shave daily (men). Don't use topical products. Use jojoba oil or moisturizer only as necessary to avoid dry skin. Avoid drugs and alcohol. Relax. Life is good!

Don’t Do This!

Avoid kelp, too much iodine (iodized salt, sea salt is ok), alcohol, drugs, harsh topical medicines like benzoyl peroxide, over-washing, antibiotics, stimulants (ritalin,caffeine) within 10 hours of bedtime, sleep deprivation, sleeping with the light on, going to the bathroom in the middle of the night (drink less water at night!).

Do Your Best

If you have acne, chances are you are violating a lot of these rules. No one expects you to fix everything at once. Make changes as you can, experiment, and see what happens. Once your skin is great, you can add back in certain foods and lifestyles that are important to you. If something turns out to be a trigger, you'll figure it out pretty quick.